Tuesday, January 3, 2012

Dr. Peggy Drexler: Happy New Year?

Even assuming that the Mayan calendar got it wrong, and the planet will not end in cataclysm -- 2012 still figures to be a tough year.

We're going to live through the bizarre primary of C-list choices, and a general election that is likely to leave us all feeling like the clean-up crew after a carnival.

Then again, maybe the Mayans saw this coming.

It will be an election where the super-PACs, by law, can spend what they want, and say what they want, about anybody they want. The candidates can claim nothing to do with any of it, while repudiating none of it.

So as much as we might want to feel the sense of hope and possibility that comes with the change of years, this is an election year. Worse, it comes in a time spittle-flecked animosity toward the effrontery of contrary opinion.

Imagine what the coming months of full-contact campaigning and mercenary assaults on character are going to do to positions already tempered by four years of political trench warfare.

Reporter and commentator Sam Donaldson once said of Washington politics: "Only the amateurs stay mad." That was politics then. Politics now is a place of molten incivility and viscous resentment. Anger is the common ground.

All due respect to Mr. Donaldson. Everybody's mad, and they're going to stay mad -- about houses, about taxes, about spending, about jobs, about inequality, about healthcare, about marriage, about faith, about immigration, about war, about security, about our shaken sense of national identity.

The irony here is the corrosive division over these issues eats away at any hope we can resolve them.

But: back to the New Year being a time of possibility.

It's possible that the economy will allow some rays of sunshine break through the low-hanging clouds of the past few years.

If it's true that the angriest people are the people who are most afraid, a calmer and more optimistic constituency might make for more collaborative representation. It might diminish the fear that giving something to get something will invite the torch-bearers of the extremes to drag you from your office come next election.

Even so, it's going to take time and courage to reach across the divisions of recent years -- where rational policy has become entangled in convoluted resentments.

In the hopes that 2012 will, in fact, be a happier year, I humbly offer this piece of advice to those who would lead us out of the dark impasse of ideologies:

"Go to hell" is no way to start a negotiation.

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Follow Dr. Peggy Drexler on Twitter: www.twitter.com/drpeggydrexler

Source: http://www.huffingtonpost.com/peggy-drexler/happy-new-year_5_b_1177827.html

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Friday, December 30, 2011

Whale sperm, orgasmic feet top 2011 bad science list

LONDON | Tue Dec 27, 2011 7:11pm EST

LONDON (Reuters) - From whale sperm to colon cleansers to the shape of a woman's foot when she has an orgasm, celebrities did not disappoint during 2011 with their penchant for peddling suspect science in the world's media.

In its annual list of what it considers the year's worst abuses against science, the Sense About Science (SAS) campaign named reality TV star Nicole Polizzi, Republican presidential candidate Michelle Bachmann and American singer-songwriter Suzi Quatro as top offenders, with their dubious views on why the sea is salty, the risks of cervical cancer vaccines and the colon.

"I used to get a lot of sore throats and then one of my sisters told me that all illnesses start in the colon. I started taking a daily colon cleanser powder mixed with fresh juice every morning and it made an enormous difference," Quatro told the Daily Mail newspaper.

But SAS was keen to dispel such myths. It asked qualified scientists from various disciplines to comment on some of the worst celebrity science offences.

"The colon is very important in some diseases, but it certainly is not the cause of all illnesses," said Melita Gordon, a consultant gastroenterologist said in the review.

"Sore throats do not come from your colon; they are caused by viruses that come in through your nose and mouth. Taking 'colon cleansers' has no beneficial effect on your throat - or on your colon."

While the review is partly about entertainment, the campaign group stresses it also has a serious aim - to make sure pseudo-science is not allowed to become accepted as true.

After Bachmann used an appearance on a television show to tell a story of a woman from Tampa, Florida, who said her daughter had become "mentally retarded" after getting an HPV vaccine designed to protect against cervical cancer, doctors said they feared the damage done may take many years to reverse.

"It's tempting to dismiss celebrity comments on science and health, but their views travel far and wide and, once uttered, a celebrity cancer prevention idea or environmental claim is hard to reverse," said SAS's managing director Tracey Brown.

"At a time when celebrities dominate the public realm, the pressure for sound science and evidence must keep pace."

The review also highlighted a bizarre quote from TV personality Polizzi, who declared recently: "I don't really like the beach. I hate sharks, and the water's all whale sperm. That's why the ocean's salty."

Simon Boxall, a marine expert and oceanographer dismissed Polizzi's suggestion. "It would take a lot of whale sperm to make the sea that salty," he said.

Some of the most intriguing pseudo-scientific suggestions came via repeated second hand information picked up at parties - never the most reliable source.

Christian Louboutin, a French footwear designer, was taken with something a fellow party guest told him about shoes.

"She said that what is sexual in a high heel is the arch of the foot, because it is exactly the position of a woman's foot when she orgasms. So putting your foot in a heel, you are putting yourself in a possibly orgasmic situation," he explained.

Kevan Wylie, a consultant in sexual medicine, responded drily that it's important to differentiate cause from effect.

"A woman's foot may be in this position during orgasm, but that does not mean that putting her foot into this position under other circumstances will result in orgasm," he said.

(Editing by Paul Casciato)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/n8xOrc6d35M/us-science-celebrities-idUSTRE7BR00G20111228

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Wednesday, December 28, 2011

Jennifer Hudson performs holiday medley at Disney Christmas Parade 2011 (Video)

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Examiners provide unique and original content to enhance life in your local city wherever that may be. Examiners come from all walks of life and contribute original content to entertain, inform, and inspire.

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Sunday, December 25, 2011

LAStory: RT Kathy Griffin Slams Kim Kardashian Wedding, Divorce on Twitter http://t.co/hXPHzVtZ via @racheldillin

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4. Finland 'finds Patriot missiles' on China-bound ship

(The Finnish authorities have impounded an Isle of Man-flagged ship bound for China with undeclared missiles and explosives, officials say.?? Awww..... Shit.?? They must have picked these up at K-Mart.? Blue light special on Patriot missiles.)

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The Thor Liberty is docked in Kotka

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December 21, 2011

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The Finnish authorities have impounded an Isle of Man-flagged ship bound for China with undeclared missiles and explosives, officials say.

Police are questioning the crew of the MS Thor Liberty after what were described as 69 Patriot anti-missile missiles were found aboard.

Interior Minister Paivi Rasanen said the missiles were marked "fireworks".

The MS Thor Liberty had docked in the Finnish port of Kotka after leaving Germany last week.

Dock workers became suspicious after finding explosives poorly stored on open pallets, and the missiles were then found in containers marked "fireworks".

The managing director of the ship's owner, Thorco Shipping, expressed surprise. Thomas Mikkelsen told AFP news agency from Denmark that he was unaware of the matter.

Another company official, speaking on condition of anonymity, confirmed the ship had been detained in Finland and said the missiles could have been loaded on to the vessel by mistake, AFP adds.

Police did not confirm Finnish media reports that the ship had also been scheduled to stop in South Korea, Reuters news agency reports.

'Quite unusual'

The MS Thor Liberty left port in Emden, northern Germany, on 13 December and docked two days later in Kotka, southern Finland, to pick up a cargo of anchor chains, said Finnish Customs spokesman Petri Lounatmaa.

It was bound for the Chinese port of Shanghai but there was no indication for whom the military cargo was destined.

Routine checks by Finland's traffic safety authority revealed a load of up to 160 tonnes of improperly packed nitroguanidine, a low-sensitivity explosive with a high detonation speed.

"Actually in our investigation at the moment, we have got the information that we found 69 Patriot missiles on the ship and around 160 tonnes of explosives," said Detective Superintendent Timo Virtanen from the Finnish National Bureau of Investigation.

Interior Minister Rasanen said she had not heard of a similar case.

"Of course, there are legal transports of weapons or defence material [through Finland] but in this case the cargo was marked as containing fireworks," she told Finnish media. "That is quite unusual."

Mr Lounatmaa said customs officials and police had launched a joint investigation into a possible breach of Finnish export and weapons trading laws.

He said that the crew of about 32 were being questioned.

Patriot missiles, designed by the US company Raytheon, are supplied to "US and allied forces", according to the company's website. South Korea is among states which deploy them.

Source: http://12160.info/xn/detail/2649739%3ABlogPost%3A732647

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Saturday, December 24, 2011

Severe congenital disorder successfully treated in a mouse model for the first time

ScienceDaily (Dec. 22, 2011) ? Using a mouse model, Heidelberg University Hospital researchers have for the first time successfully treated a severe congenital disorder in which sugar metabolism is disturbed. The team headed by Prof. Christian K?rner, group leader at the Center for Child and Adolescent Medicine, demonstrated that if female mice are given mannose with their drinking water prior to mating and during pregnancy, their offspring will develop normally even if they carry the genetic mutation for the congenital disorder. The team's outstanding work will contribute to better understanding of the molecular processes of this metabolic disease, along with the key stages in embryonic development, and may offer a therapeutic approach for the first time.

The Heidelberg-based researchers also collaborated with colleagues working with Prof. Hermann-Josef Gr?ne of the German Cancer Research Center (DKFZ)'s Division of Cellular and Molecular Pathology in Heidelberg. Their results have now been published online in the journal Nature Medicine in advance of their publication in the print edition.

Rare disease: Approx. 1,000 children affected

So far 1,000 children worldwide are affected by congenital disorders of glycosylation (CDG), which are classified as rare diseases. Affecting around 800 children, type CDG-Ia is most frequent. The number of unreported cases is high, however. Children with CDG are severely physically and mentally disabled, with approx. 20 percent dying before the age of two. To date, no therapy has been available to treat the disorder.

CDG-Ia is caused by mutations in the genetic information for the enzyme Phosphomannomutase 2 which is involved in important glycosylation processes: Mannose-1-phosphate is not produced in sufficient quantities. As a result, glycosylation malfunctions, meaning that sugar chains that normally aid in form, stability and function of the glycoproteins are not completely attached to the body's proteins or in some cases, are not attached at all. The lack of oligosaccharide chains leads to impairment of neurological, growth and organ development. The disorder only manifests if the baby inherits a mutated gene from both the mother and the father. The parents, who each carry one mutated and one "healthy" copy of the gene, do not exhibit any symptoms.

Mice take up mannose in drinking water

The mouse model developed by Prof. K?rner and his team is characterized by mutations in the Phosphomannomutase 2 gene and demonstrates reduced enzyme activity, comparable to CDG-Ia in man. In their current study, the scientists exploited the ability of mannose to cross the placental barrier. This means that if the pregnant mouse takes up mannose, it also reaches the embryos in the uterus.

"One week prior to mating, we began giving the female mice mannose with their drinking water," explained biochemist Prof. K?rner. The additional mannose supply up to birth increased the mannose levels in the embryos' blood. "The mice were born without defects and also after they were born, developed without any symptoms of the disorder, even if they no longer took up any mannose," K?rner added. The successful studies performed by the Heidelberg University Hospital researchers clearly show the key role played by the supply of proteins with sugar chains during embryonic development.

New therapeutic approach

"Clinical studies in the U.S. and Germany have already been performed in which children with CDG-Ia were given mannose after they were born, either orally or by intravenous infusion. Unfortunately, these attempts have not been successful," explained Dr. Christian Thiel, head of the laboratory. "This means that the critical point at which it is possible to influence development must be during development in the uterus." For women with a risk of CDG-Ia, administering mannose during pregnancy may serve as a new therapeutic approach.

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The above story is reprinted from materials provided by University Hospital Heidelberg.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Anette Schneider, Christian Thiel, Jan Rindermann, Charles DeRossi, Diana Popovici, Georg F Hoffmann, Hermann-Josef Gr?ne, Christian K?rner. Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice. Nature Medicine, 2011; DOI: 10.1038/nm.2548

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111222103044.htm

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